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Serum IgM and IgG antibody response six months post-COVID-19 vaccination / 上海预防医学
Shanghai Journal of Preventive Medicine ; (12): 126-129, 2022.
Article in Chinese | WPRIM | ID: wpr-920785
ABSTRACT
Objective To determine the serum IgM and IgG antibody levels post-COVID-19 vaccination, and provide scientific evidence for COVID-19 antibody response after vaccination. Methods A total of 980 healthy persons were included in Kunming Third People’s Hospital from July through August, 2021, which had been vaccinated with COVID-19 vaccines and then tested for anti-SARS-CoV-2 IgM and IgG antibodies. Results After the COVID-19 vaccination, 469 persons (positive rate, 47.86%) were positive for anti-IgG antibody. Of them, 75 were males with (positive rate, 39.06%), and the average IgG level was 0.618 (0.180, 2.526) AU·mL-1[M(Q1,Q3)]; 394 were females (50.00%), and the IgG level was 0.999 (0.305, 3.334) AU·mL-1. In addition, 53 persons (5.41%) were anti-IgM antibody positive. Of them, 14 were males (positive rate, 7.29%), and the average IgM level was 0.057 (0.026, 0.195) AU·mL-1; 39 were females (4.95%), and the IgM level was 0.047 (0.027, 0.110) AU·mL-1. The positive rate of anti-IgG antibody was highest in those aged ≤30 years, which was 51.02% in male (n=25) and 55.88% in female (n=133). The anti-IgG response differed significantly by gender (χ2=7.401, D=0.135 1, P<0.05), whereas the anti-IgM response was not significantly different (χ2=1.656, P>0.05). Among the age groups, anti-IgG antibody level was higher in those aged ≤30 and 51-70 years, with 158 (55.05%) and 122 (52.36%) persons, respectively; the average antibody level was 1.209 (0.426, 4.386) AU·mL-1 and 1.074 (0.191, 7.670) AU·mL-1, respectively. The differences in the positive rates of IgG and IgM antibodies and the levels of IgG antibodies among different age groups were statistically significant (P<0.05). Using Kruskal-Wallis test and Spearman correlation analysis, it showed a high correlation between the IgG and IgM antibodies (r=0.836 4, H=64.82, 20.09, P<0.05). Conclusion The Anti-SARS-CoV-2 IgG antibody remains high six months post-COVID-19 vaccination, while anti-IgM antibody is low. The IgM and IgG response are higher in the young and elderly. The response differs by gender and age, demonstrating a correlation.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Shanghai Journal of Preventive Medicine Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Shanghai Journal of Preventive Medicine Year: 2022 Type: Article