Unfolded protein response signaling in mitochondria / 生理学报
Acta Physiologica Sinica
;
(6): 835-844, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-921287
ABSTRACT
The mitochondrial unfolded protein response is an important component of the mitochondrial protein quality control program. It can effectively remove unfolded or misfolded proteins under stress, and maintain a stable and healthy mitochondrial pool. The mitochondrial unfolded protein response is coordinated by multiple signaling pathways. The classical ATF4/ATF5-CHOP pathway is induced by accumulation of unfolded or misfolded proteins in the mitochondrial matrix, which reduces stress toxicity by regulating molecular chaperones and proteases. Sirt3-FOXO3a-SOD2 pathway, located in the mitochondrial matrix, plays an important role in anti-oxidative damage. The ERα-NRF1-HTRA2 pathway mainly removes unfolded proteins in the mitochondrial membrane space and improves the quality control of mitochondrial proteins. These three signaling pathways work both independently and cooperatively to enhance mitochondrial capacity and maintain health under stress.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
Oxidative Stress
/
Mitochondrial Proteins
/
Unfolded Protein Response
/
Mitochondria
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2021
Type:
Article
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