Research advances of occludin in vascular endothelial injury / 生理学报
Acta Physiologica Sinica
;
(6): 931-939, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-921298
ABSTRACT
Endothelial tight junctions (TJs) serve as an important barrier in vascular endothelial structure and maintain vascular function homeostasis. Occludin, the most representative tight junction protein, is involved in sealing cell connections and maintaining the integrity and permeability of vascular endothelium. Recent studies have shown that alterations in the expression, distribution, and structure of endothelial TJs may lead to many related vascular diseases and pathologies (such as stroke, atherosclerosis, and pulmonary hypertension etc.). Here, we reviewed the research advances on the relationship between occludin and vascular endothelial injury, including the biological information of occludin, the signal pathways that occludin exerts the protective effect of vascular endothelium, and the relationship between occludin and vascular endothelial injury-related diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Endothelium, Vascular
/
Signal Transduction
/
Tight Junctions
/
Occludin
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2021
Type:
Article
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