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Effect of RhoE expression on the migration and invasion of tongue squamous cell carcinoma / 华西口腔医学杂志
West China Journal of Stomatology ; (6): 510-517, 2021.
Article in English | WPRIM | ID: wpr-921367
ABSTRACT
OBJECTIVES@#This study aims to investigate the effect of RhoE expression on the migration and invasion of tongue squamous cell carcinoma (TSCC).@*METHODS@#Forty-eight TSCC cases were selected from the Maxillofacial Surgery Center of Qingdao Municipal Hospital from 2017 to 2019. The expression of RhoE in the specimens (TSCC and adjacent tissues) was detected by immunohistochemistry, and RhoE mRNA and protein were extracted to further detect the expression of RhoE. SCC-4 and CAL-27 cells were selected for @*RESULTS@#The expression level of RhoE in TSCC was significantly lower than that in adjacent tissues (@*CONCLUSIONS@#RhoE expression is low in TSCC. Over expression RhoE in TSCC can significantly decrease its migration and invasion abilities. Hence, RhoE may play an important role in regulating the metastasis and invasion of TSCC and provide a new target for gene therapy.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tongue / Tongue Neoplasms / Carcinoma, Squamous Cell / Rho GTP-Binding Proteins / Matrix Metalloproteinase 2 / Cell Line, Tumor / Rho-Associated Kinases / Neoplasm Invasiveness Limits: Humans Language: English Journal: West China Journal of Stomatology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tongue / Tongue Neoplasms / Carcinoma, Squamous Cell / Rho GTP-Binding Proteins / Matrix Metalloproteinase 2 / Cell Line, Tumor / Rho-Associated Kinases / Neoplasm Invasiveness Limits: Humans Language: English Journal: West China Journal of Stomatology Year: 2021 Type: Article