Expanding the concept of patient-derived xenografts cohorts in head and neck cancer: current and future perspectives / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 617-623, 2021.
Article
in English
| WPRIM
| ID: wpr-921383
ABSTRACT
Head and neck cancer is the seventh common cancer in the world, and various existing treatment strategies provide modest benefit for most patients with head and neck cancer. Meanwhile, therapeutic strategies lacking molecular typing significantly hinder the development of individualized treatment for head and neck cancer. In recent years, connected by preclinical models, the novel ideal has gradually reached a consensus in terms of facilitating inter-transformation of clinical problems and basic achievements. As a bridge between basic research and clinical transformation, patient-derived xenografts (PDX) models precisely replicate genetic characteristics and tumor evolution, which are displaying great vitality in elucidating the mechanism of tumorigenesis and progression. Moreover, cohorts composed of several PDX models highlight the unique advantages of mice for drug screening and biomarker analysis for patients. This ideal preclinical model explores potential treatment strategies suited the ethical standards as much as possible for patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Xenograft Model Antitumor Assays
/
Disease Models, Animal
/
Heterografts
/
Head and Neck Neoplasms
Type of study:
Practice guideline
/
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
West China Journal of Stomatology
Year:
2021
Type:
Article
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