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Role and mechanism of necrostin-1 in promoting oxidative stress response of macrophages in high glucose condition / 华西口腔医学杂志
Article in English | WPRIM | ID: wpr-921390
Responsible library: WPRO
ABSTRACT
OBJECTIVES@#To investigate the role and molecular mechanism of necrostatin-1 (Nec-1), a specific programmed cell necrosis inhibitor, in promoting the oxidative stress response of macrophages under high glucose (HG) environment.@*METHODS@#Macrophages were cultured in control (5.5 mmol·L@*RESULTS@#The HG group had increased ROS level and MDA activity (@*CONCLUSIONS@#HG promotes oxidative stress on macrophages by upregulating RIP1 expression.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Humans / Reactive Oxygen Species / Oxidative Stress / Glucose / Macrophages / Necrosis Language: English Journal: West China Journal of Stomatology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Humans / Reactive Oxygen Species / Oxidative Stress / Glucose / Macrophages / Necrosis Language: English Journal: West China Journal of Stomatology Year: 2021 Type: Article