Role and mechanism of necrostin-1 in promoting oxidative stress response of macrophages in high glucose condition / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 675-681, 2021.
Article
in English
| WPRIM
| ID: wpr-921390
ABSTRACT
OBJECTIVES@#To investigate the role and molecular mechanism of necrostatin-1 (Nec-1), a specific programmed cell necrosis inhibitor, in promoting the oxidative stress response of macrophages under high glucose (HG) environment.@*METHODS@#Macrophages were cultured in control (5.5 mmol·L@*RESULTS@#The HG group had increased ROS level and MDA activity (@*CONCLUSIONS@#HG promotes oxidative stress on macrophages by upregulating RIP1 expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reactive Oxygen Species
/
Oxidative Stress
/
Glucose
/
Macrophages
/
Necrosis
Limits:
Humans
Language:
English
Journal:
West China Journal of Stomatology
Year:
2021
Type:
Article
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