Research progress of AFP in the diagnosis and therapy of hepatocellular carcinoma / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 3042-3060, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-921405
ABSTRACT
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths and the fifth most common cancer worldwide. Clinically therapeutic options for HCC are very limited, and the overall survival rate of patients is very low. Therefore, early diagnosis and treatment of HCC have important impact on overall survival of patients. At present, alpha-fetoprotein (AFP) is one of the most widely used serological markers for HCC. Many evidences have shown that as a specific onco-protein, AFP has great research value in the occurrence, development, diagnosis and treatment of HCC. Here, we briefly introduce the molecular mechanism of AFP in the regulation of HCC occurrence and development, and its role in tumor escape from immune surveillance. We focus on the application of AFP as an important HCC target or carcino-embryonic antigen (CEA) in HCC clinical diagnosis and treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Alpha-Fetoproteins
/
Biomarkers, Tumor
/
Carcinoma, Hepatocellular
/
Early Detection of Cancer
/
Liver Neoplasms
Type of study:
Diagnostic study
/
Screening study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2021
Type:
Article
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