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Advances in the release mechanisms of bluetongue virus / 生物工程学报
Chinese Journal of Biotechnology ; (12): 3179-3189, 2021.
Article in Chinese | WPRIM | ID: wpr-921415
ABSTRACT
Bluetongue virus (BTV) causes Bluetongue (BT) of ruminants vectored by culicoides midges. It is also a classic model for studying the release mechanism of non-enveloped virus. This review begins with the infection and assembly of BTV, then summarizes the advances of different ways of releasing BTV. This includes BTV-induced autophagy and the release as extracellular vesicles via multivesicular bodies, BTV-induced apoptosis and the lytic release, as well as different pathways of release through budding via plasma membrane. The regulatory mechanisms of NS3 which is a key non-structural protein during the release of BTV are also discussed, providing a basis for further understanding the molecular mechanisms underpinning the infection, proliferation and release of BTV.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Sheep / Ceratopogonidae / Viral Nonstructural Proteins / Bluetongue / Bluetongue virus Limits: Animals Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Sheep / Ceratopogonidae / Viral Nonstructural Proteins / Bluetongue / Bluetongue virus Limits: Animals Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2021 Type: Article