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Advances of Cas9/sgRNA delivery system for gene editing / 生物工程学报
Chinese Journal of Biotechnology ; (12): 3880-3889, 2021.
Article in Chinese | WPRIM | ID: wpr-921473
ABSTRACT
In the application of CRISPR genome editing, direct cellular delivery of non-replicable Cas9/sgRNA may reduce unwanted gene targeting and integrational mutagenesis, thus offering greater specificity and safety. Cas9/sgRNA delivery system holds great potential for treating genetic diseases. This review summarizes the advances of Cas9/sgRNA delivery systems and its therapeutic applications, providing new understandings and inspirations for vector design and future clinical applications.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: CRISPR-Cas Systems / Gene Editing Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: CRISPR-Cas Systems / Gene Editing Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2021 Type: Article