Advances of targeted protein degradation technology and its applications in diseases therapy / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 3915-3932, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-921476
ABSTRACT
Targeted protein degradation (TPD) technology facilitates specific and efficient degradation of disease-related proteins through hijacking the two major protein degradation systems in mammalian cells ubiquitin-proteasome system and lysosome pathway. Compared with traditional small molecule-inhibitors, TPD-based drugs exhibit the characteristics of a broader target spectrum. Compared with techniques interfere with protein expression on the gene and mRNA level, TPD-based drugs are target-specific, efficaciously rapid, and not constrained by post-translational modification of proteins. In the past 20 years, various TPD-based technologies have been developed. Most excitingly, two TPD-based therapeutic drugs have been approved by FDA for phase Ⅰ clinical trials in 2019. Despite of the early stage characteristics and various obstructions of the TPD technology, it could serve as a powerful tool for the development of novel drugs. This review summarizes the advances of different degradation systems based on TPD technologies and their applications in disease therapy. Moreover, the advantages and challenges of various technologies were discussed systematically, with the aim to provide theoretical guidance for further application of TPD technologies in scientific research and drug development.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Technology
/
Proteins
/
Protein Processing, Post-Translational
/
Proteasome Endopeptidase Complex
/
Proteolysis
Type of study:
Practice guideline
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2021
Type:
Article
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