Advances of Kunitz-type serine protease inhibitors / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 3988-4000, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-921480
ABSTRACT
Kunitz-type serine protease inhibitors are a class of ubiquitous protease inhibitors, which play important roles in various life activities. The structures of such inhibitors are generally stable, and are usually characterized by the presence of one or several Kunitz domains in tandem, which are able to bind to serine proteases in a manner similar to substrate binding, thereby inhibiting enzyme activity. In terms of function, Kunitz-type serine protease inhibitors are involved in processes such as blood coagulation and fibrinolysis, tumor immunity, inflammation regulation, and resistance to bacterial and fungal infections. This article summarizes the advances of Kunitz-type serine protease inhibitors and provides new ideas for the development of novel Kunitz-type serine protease inhibitors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protease Inhibitors
/
Serine Proteinase Inhibitors
/
Serine Proteases
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2021
Type:
Article
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