Advances in the biosynthesis of pentostatin / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 4158-4168, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-921496
ABSTRACT
Pentostatin is a nucleoside antibiotics with a strong inhibitory effect on adenosine deaminase, and is widely used in the clinical treatment of malignant tumors. However, the high cost hampers its application. In the past 10 years, the biosynthesis of pentostatin were focused on strain breeding, optimization of medium composition and fermentation process. To date, there are no reviews summarizing the elucidated biosynthetic mechanism of pentostatin. This review starts by introducing the various chemical route for production of pentostatin, followed by summarizing the mechanisms of pentostatin biosynthesis in different microorganisms. Finally, challenges for biosynthesis of pentostatin were discussed, and strategies for regulating and improving the microbial synthesis of pentostatin were proposed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pentostatin
/
Anti-Bacterial Agents
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2021
Type:
Article
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