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Expression of Runt-related Transcription Factor 3 in Human Colon Cancer Cell Line HCT-116 Resistant to 5-Fluorouracil and the Mechanism of Drug Resistance / 中国医学科学院学报
Shuang FAN; Xue-Liang WU; Jun XUE; Dan-Dan XU; Yan-Jun HAN; Yuan-Rui LI; Ming QU.
Acta Academiae Medicinae Sinicae ; (6): 706-715, 2021.
Article in Chinese | WPRIM | ID: wpr-921529
ABSTRACT
Objective To establish a human colon cancer cell line HCT-116/5-FU resistant to 5-fluorouracil(5-FU)and explore the relationship between runt-related transcription factor 3(RUNX3)and drug resistance of colorectal cancer.Methods The human colon cancer cell line HCT-116/5-FU with resistance to 5-FU was established by low concentration gradient increment combined with high-dose intermittent shock.CCK-8 method was used to determine the half maximal inhibitory concentration(IC
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Colonic Neoplasms / Drug Resistance, Neoplasm / Cell Line, Tumor / Core Binding Factor Alpha 3 Subunit / Transcription Factor 3 / Fluorouracil Limits: Humans Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Colonic Neoplasms / Drug Resistance, Neoplasm / Cell Line, Tumor / Core Binding Factor Alpha 3 Subunit / Transcription Factor 3 / Fluorouracil Limits: Humans Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2021 Type: Article