Role of Vascular Aging in the Pathogenesis of Abdominal Aortic Aneurysm and Potential Therapeutic Targets / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 962-968, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-921566
ABSTRACT
Abdominal aortic aneurysm(AAA)is a common aortic degenerative disease in the elderly,and its incidence is gradually increasing with the aging of the population.There are no specific drugs available to delay the expansion of AAA.Once the aneurysm ruptures,the mortality will exceed 90%,which seriously threatens the life of patients.Given the high incidence of AAA in the elderly,this review discusses the role of vascular aging in the pathogenesis of AAA,involving chronic inflammation,oxidative stress,mitochondrial dysfunction,protein homeostasis imbalance,increased apoptosis and necrosis,extracellular matrix remodeling,nutritional sensing disorders,epigenetic changes,and increased pro-aging factors.Meanwhile,several potential aging-related drug targets of AAA are listed.This review provides new ideas for basic and translational medical research of AAA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta, Abdominal
/
Aging
/
Aortic Aneurysm, Abdominal
/
Oxidative Stress
/
Disease Models, Animal
/
Muscle, Smooth, Vascular
Type of study:
Etiology study
/
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2021
Type:
Article
Similar
MEDLINE
...
LILACS
LIS