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A photothermal/chemotherapy injectable paclitaxel gel with irradiation stability / 生物医学工程学杂志
Journal of Biomedical Engineering ; (6): 979-985, 2021.
Article in Chinese | WPRIM | ID: wpr-921836
ABSTRACT
The aim of this study is to construct an injectable gel with stable phototherapy and chemotherapy. Res-PTX@IR780 gel with phototherapy and chemotherapy property was prepared by introduction of photosensitizer IR780 and antioxidant resveratrol (Res) into the polyethylene glycol (PEG) solution of paclitaxel (PTX). The results showed that PTX, PTX@IR780 and Res-PTX@IR780 could form gels and the gels were injectable. ATR-FTIR results indicated not only components of the gels but also the formation of hydrogen bonding during the gelation. The results of UV showed instability of IR780 solution and stability improvement of Res-IR780 solution under infrared radiation (IR) irradiation. Photothermal tests showed that Res-PTX@IR780 displayed better photothermal conversion and photothermal stability under multiple irradiations than PTX@IR780. The results of
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phototherapy / Paclitaxel / Cell Line, Tumor / Nanoparticles / Gels / Hyperthermia, Induced / Mice, Inbred BALB C Limits: Animals Language: Chinese Journal: Journal of Biomedical Engineering Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phototherapy / Paclitaxel / Cell Line, Tumor / Nanoparticles / Gels / Hyperthermia, Induced / Mice, Inbred BALB C Limits: Animals Language: Chinese Journal: Journal of Biomedical Engineering Year: 2021 Type: Article