Pamidronate Therapy in Children and Adolescents with Secondary Osteoporosis / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology
;
: 178-184, 2011.
Article
in Korean
| WPRIM
| ID: wpr-92210
ABSTRACT
PURPOSE:
The aim of this study was to evaluate the efficacy of pamidronate therapy in children and adolescents with secondary osteoporosis.METHODS:
Nine patients (7 males, 2 females, 13.2 +/- 2.5 years, 10.1-17.4 years) with secondary osteoporosis who had a history of severe bone pain and/or fracture were enrolled. Intravenous pamidronate 1.5 mg/kg (0.5 mg/kg for 3 consecutive days) was given every 6 to 8 weeks for 0.86 +/- 0.15 years (6 or 8 cycles). Bone mineral density (BMD) in lumbar spine and femoral neck and their Z-scores were measured before treatment, after the fourth and last cycle (sixth or eighth cycle).RESULTS:
Underlying diseases were as follows; neurofibromatosis type 1 (n = 2), epilepsy with/without cerebral palsy (N=2), autoimmune disease treated with steroid (n = 2), hematologic malignancy (n = 3). Bone pain was relieved in most of the patients after the first cycle of treatment, and no more fracture occurred thereafter. There was a significant increase in BMD Z-score of the lumbar spine and femoral neck after the last cycle of therapy, compared to baseline values (from -3.91 +/- 1.79 to 1.86 +/- 1.18, in L1-4 and -3.71 +/- 1.83 to -2.53 +/- 1.77 for femoral neck; P = 0.008 and 0.011, respectively). However, there was no significant change in BMD Z-scores between the fourth cycle and the last cycle. Fever developed in 7 out of 9 patients (77.8%), which was relieved by antipyretics. Total serum levels of calcium and phosphorus were significantly decreased (calcium, P = 0.008; phosphorus, P = 0.015) after pamidronate therapy, and three of them experienced symptomatic hypocalcemia during the first cycle. The growth velocity was normal during follow-up periods (mean, 4.47 +/- 1.69 years; range, 1.05 to 6.77 years).CONCLUSION:
In conclusion, pamidronate can be administered to the patients with secondary osteoporosis, relieving the symptoms and signs effectively and safely. However, its side effects should be monitored during treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoporosis
/
Phosphorus
/
Autoimmune Diseases
/
Spine
/
Bone Density
/
Cerebral Palsy
/
Calcium
/
Follow-Up Studies
/
Neurofibromatosis 1
/
Hematologic Neoplasms
Type of study:
Observational study
/
Prognostic study
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
Journal of Korean Society of Pediatric Endocrinology
Year:
2011
Type:
Article
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