Elemene Emulsion Injection Administration Reduces Neuropathic Pain by Inhibiting Astrocytic NDRG2 Expression within Spinal Dorsal Horn / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 912-918, 2021.
Article
in English
| WPRIM
| ID: wpr-922103
ABSTRACT
OBJECTIVE@#To investigate the mechanisms underlying elemene-induced analgesia in rats with spared nerve injury (SNI).@*METHODS@#Sixty-five rats were equally divided into 5 groups using a random number table naive group, sham group, SNI group, SNI + elemene (40 mg·kg@*RESULTS@#The SNI rat model exhibited a significant decrease in paw withdrawal threshold and exploratory behaviour in the EPM (P<0.05). Consecutive administration of elemene alleviated SNI-induced mechanical allodynia and anxiety in rats (P<0.05). Immunohistochemical data showed that elemene decreased SNI-induced upregulation of NDRG2 within the SDH (P<0.05). Double immunofluorescent staining data further showed that elemene decreased SNI-induced upregulation of the number of GFAP immunoreactive (-ir), NDRG-ir, and GFAP/NDRG2 double-labelled cells within the SDH (P<0.05). Immunoblotting data showed that elemene decreased SNI-induced upregulation of GFAP and NDRG2 within the SDH (P<0.05).@*CONCLUSION@#Elemene possibly alleviated neuropathic pain by downregulating the expression of NDRG2 in spinal astrocytes in a rat model of SNI.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sesquiterpenes
/
Spinal Cord
/
Astrocytes
/
Rats, Sprague-Dawley
/
Disease Models, Animal
/
Emulsions
/
Spinal Cord Dorsal Horn
/
Hyperalgesia
/
Nerve Tissue Proteins
/
Neuralgia
Limits:
Animals
Language:
English
Journal:
Chinese journal of integrative medicine
Year:
2021
Type:
Article
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