Arsenic Trioxide Combining Leflunomide Activates Nrf2-ARE-HO-1 Signaling Pathway and Protects Heart Xenografts / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 760-766, 2021.
Article
in English
| WPRIM
| ID: wpr-922118
ABSTRACT
OBJECTIVE@#To investigate the molecular mechanisms underlying the effects of arsenic trioxide (As@*METHODS@#Transplantation of LVG hamster hearts to Lewis rats was performed by anastomosis of vessels in the neck using end-to-end anastomosis with a non-suture cuff technique. Four groups of recipient rats (n=6 in each) were treated with normal saline (control), As@*RESULTS@#Expression of Nrf2-ARE-HO-1 signaling pathway was upregulated in heart xenografts in rats treated with As@*CONCLUSION@#Combination treatment with As
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rats, Inbred Lew
/
Signal Transduction
/
Heart Transplantation
/
Heme Oxygenase-1
/
NF-E2-Related Factor 2
/
Heterografts
/
Arsenic Trioxide
/
Leflunomide
Limits:
Animals
Language:
English
Journal:
Chinese journal of integrative medicine
Year:
2021
Type:
Article
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