Prostate health index for the diagnosis of prostate cancer in Asians in Macau with a PSA level of 4-10 μg/L / 中华男科学杂志
National Journal of Andrology
;
(12): 803-808, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-922161
ABSTRACT
Objective@#To evaluate the prostate health index (PHI) as a tool for the diagnosis of PCa with a PSA level of 4-10 μg/L and determine the best cut-off value of PHI.@*METHODS@#Fifty-eight patients with a PSA level of 4-10 μg/L underwent transrectal ultrasound-guided prostatic biopsy in our hospital between April 2017 and June 2019. We constructed receiver operating characteristic (ROC) curves for the relationship of the biopsy results with the level of PSA, the ratio of [-2] proPSA to fPSA and PHI, and calculated the area under the ROC curves (AUC).@*RESULTS@#Prostatic biopsy revealed 18 cases of PCa in the 58 patients (31.0%). Statistically significant differences were observed between the PCa and non-PCa groups in [-2] proPSA, %[-2] proPSA and PHI, but not in tPSA, % fPSA and PSA-density. The AUCs of PSA, % fPSA, PSA-density, [-2] proPSA, %[-2] proPSA and PHI were 0.556, 0.407, 0.533, 0.746, 0.751 and 0.774, respectively. The specificity of PHI was 27.50% (95% CI 14.6%-43.9%), the highest among the above predictors at 90% sensitivity. By applying PHI to this cohort, 13 cases (22.4%) of unnecessary biopsy could be avoided.@*CONCLUSIONS@#The application of PHI can increase the accuracy of PCa prediction and reduce unnecessary prostatic biopsy.、.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Prostatic Neoplasms
/
Prostate-Specific Antigen
/
Asian People
/
Macau
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2021
Type:
Article
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