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Early life blood lead levels and asthma diagnosis at age 4-6 years
Environmental Health and Preventive Medicine ; : 108-108, 2021.
Article in English | WPRIM | ID: wpr-922202
ABSTRACT
The USA has a high burden of childhood asthma. Previous studies have observed associations between higher blood lead levels and greater hypersensitivity in children. The objective of the present study was to estimate the association between blood lead concentrations during early childhood and an asthma diagnosis between 48 and 72 months of age amongst a cohort with well-characterized blood lead concentrations. Blood lead concentrations were measured at 6, 12, 18, 24, 36, and 48 months of age in 222 children. The presence of an asthma diagnosis between 48 and 72 months was assessed using a questionnaire which asked parents or guardians whether they had been told by a physician, in the past 12 months, that their child had asthma. Crude and adjusted risk ratios (RR) of an asthma diagnosis were estimated for several parameterizations of blood lead exposure including lifetime average (6 to 48 months) and infancy average (6 to 24 months) concentrations. After adjustment for child sex, birthweight, daycare attendance, maternal race, education, parity, breastfeeding, income, and household smoking, age-specific or composite measures of blood lead were not associated with asthma diagnosis by 72 months of age in this cohort.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Asthma / New York / Cohort Studies / Environmental Pollutants / Lead Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Risk factors Limits: Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: North America Language: English Journal: Environmental Health and Preventive Medicine Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Asthma / New York / Cohort Studies / Environmental Pollutants / Lead Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Risk factors Limits: Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: North America Language: English Journal: Environmental Health and Preventive Medicine Year: 2021 Type: Article