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Clinical Characteristics and Prognosis Analysis of Pediatric Severe Aplastic Anemia / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1896-1902, 2021.
Article in Chinese | WPRIM | ID: wpr-922220
Responsible library: WPRO
ABSTRACT
OBJECTIVE@#To analyze the clinical characteristics and factors affecting prognosis in children with severe aplastic anemia (SAA).@*METHODS@#Two hundred and five children with SAA treated in our department from January 2008 to April 2018 were selected, and the clinical characteristics and factors affecting prognosis were retrospectively analyzed.@*RESULTS@#Among 205 SAA children, the effective rate (CR+PR) at 3, 6 and 12 months after immunosuppressive therapy (IST) treatment was 50.9%, 59.0% and 73.9%, respectively, and 5-year overall survival rate was 93.1%±2.0%. Univariate analysis showed that 5-year overall survival rate of SAA children of spontaneous delivery was higher than that of cesarean section (P=0.039), while multivariate analysis showed that birth way had no significant influence on 5-year overall survival rate (P>0.05). The response rate at 3 months after IST of children with a recent history of decoration before SAA onset was higher than those without history of decoration (P<0.05).@*CONCLUSION@#Most of the SAA children can achieve high response rate and overall survival rate. Patients with recent history of home/school decoration may be the factor affecting hematological response after 3 months of IST, but have no influence on long-term overall survival.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Female / Humans / Pregnancy / Cesarean Section / Child / Retrospective Studies / Treatment Outcome / Immunosuppressive Agents / Anemia, Aplastic Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Female / Humans / Pregnancy / Cesarean Section / Child / Retrospective Studies / Treatment Outcome / Immunosuppressive Agents / Anemia, Aplastic Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article