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Hb Bart's Quantitative Analysis in the Screening of α-Thalassemia / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1903-1906, 2021.
Article in Chinese | WPRIM | ID: wpr-922221
ABSTRACT
OBJECTIVE@#To research the relationship between difference types of α-thalassemia gene types and Hb Bart's hemoglobin bands.@*METHODS@#Capillary electrophoresis was used to screen thalassemia gene for the newborn form January 2020 to December 2020, and the thalassemia gene was detected by PCR or PCR-NGS in the positive patients. The relationship between α-thalassemia gene and Hb Bart's hemoglobin was compared and analyzed statistically.@*RESULTS@#There were significant differences in Hb Bart's hemoglobin among the different α-thalassemia mutation types, Hb Bart's was the highest in --SEA/-α@*CONCLUSION@#The Hb Bart's content of different genotypes of α-thalassemia are significantly different. The Hb Bart's content shows high application value in α-thalassemia screening and genotyping identification.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Hemoglobins, Abnormal / Polymerase Chain Reaction / Alpha-Thalassemia / Heterozygote Type of study: Diagnostic study / Screening study Limits: Humans / Infant, Newborn Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Hemoglobins, Abnormal / Polymerase Chain Reaction / Alpha-Thalassemia / Heterozygote Type of study: Diagnostic study / Screening study Limits: Humans / Infant, Newborn Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article