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Research Progress of Thalidomide and Its Derivatives in Treatment of Myelodysplastic Syndrome--Review / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1967-1971, 2021.
Article in Chinese | WPRIM | ID: wpr-922233
ABSTRACT
Thalidomide and its derivatives have been used in the treatment of myelodysplastic syndrome (MDS) because of their anti-angiogenic and immunomodulatory effects. In recent years, some studies have found that thalidomide and its derivatives not only showed significant efficacy in lower-risk MDS patients with del (5q), but also showed advantages in non-del (5q) MDS patients. In addition, the discovery of its molecular targets and new substrates makes it possible to develop a new generation of immunomodulatory drugs (IMiDs) and to design IMiDs-based proteolysis-targeting chimeras. In this review, the new progress in mechanism and clinical application of thalidomide and its derivatives were summarized briefly, so as to provide a more scientific, reasonable and effective scheme to the treatment of MDS.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Thalidomide / Myelodysplastic Syndromes / Immunomodulating Agents Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Thalidomide / Myelodysplastic Syndromes / Immunomodulating Agents Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article