Natural medicinal ingredients induce tumor ferroptosis and related mechanisms / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 601-606, 2021.
Article
in English
| WPRIM
| ID: wpr-922257
ABSTRACT
Ferroptosis is an iron-dependent programmed cell death characterized by reactive oxygen species-induced lipid peroxide accumulation, which is different from cell apoptosis, pyroptosis, necrosis or autophagy. Ferroptosis plays an important role in the regulation of tumorigenesis and tumor development. Recent studies have shown that natural medicinal ingredients can induce ferroptosis in tumor cells through glutathione (GSH)/glutathione peroxidase 4 (GPx4) pathway, iron metabolism, lipid metabolism or other mechanisms. It has been reported that more than 30 natural medicinal ingredients can induce ferroptosis in tumor cells with multiple pathways and multiple targets. This article reviews the current research progress on the antitumor effects of natural medicinal ingredients through inducing cell ferroptosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autophagy
/
Reactive Oxygen Species
/
Apoptosis
/
Ferroptosis
/
Neoplasms
Limits:
Humans
Language:
English
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2021
Type:
Article
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