The Clinical Characteristics and Outcomes of the Patients with POEMS Syndrome / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1645-1648, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-922309
ABSTRACT
OBJECTIVE@#To analyze the clinical characteristics of patients with POEMS syndrome and explore its effective treatment strategies.@*METHODS@#The clinical data of 75 patients with POEMS syndrome treated in The First Affiliated Hospital of Zhengzhou University from June 2012 to June 2018 were collected and retrospectively analyzed. The clinical characteristics, treatment regimes and outcomes of the patients were summarized.@*RESULTS@#The median age of 75 diagnosed patients was 50 (30-81) years old and 100% (75/75) of the patients were accompanied with peripheral neuropathy, 77.3% (58/75) with organ enlargement, 82.7% (62/75) with endocrine abnormality, 93.3% (70/75) with monoclonal plasma cell diseases and 64.0% (48/75) with skin changes. Among the 75 patients, 5 cases gave up treatment, while the others showed varying degrees of improvement after treatment. The hematological complete remission (CR@*CONCLUSION@#The clinical manifestations of POEMS syndrome are complex and diverse, the clinicians therefore should be vigilant to reduce the misdiagnosis and missed diagnosis. Bortezomib or Lenalidomide can be recommended as the first-line medicines and autologous HSCT should be considered for appropriate patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transplantation, Autologous
/
Retrospective Studies
/
POEMS Syndrome
/
Hematopoietic Stem Cell Transplantation
/
Lenalidomide
Type of study:
Observational study
Limits:
Aged
/
Aged80
/
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2021
Type:
Article
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