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The Mutated Gene Sequenced by NGS and the Correlation of Their Coexistent Mutual Exclusiveness in NPM1 Mutated Acute Myeloid Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1733-1740, 2021.
Article in Chinese | WPRIM | ID: wpr-922326
ABSTRACT
OBJECTIVE@#To analyze the clinicobiological heterogeneity of NPM1 mutated (NPM1@*METHODS@#The NGS data based on 112 genes related to blood disease in 238 newly diagnosed patients with NPM1@*RESULTS@#Among all the patients, at least one co-mutation was detected out. The median number per case of the mutated genes, including NPM1@*CONCLUSION@#Prognoses of AML involving less common NPM1 missense mutations should be stated on a case by case basis. The mutational landscape and co-occurrence and mutual exclusivity correlations of NPM1
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Nuclear Proteins / Base Sequence / Leukemia, Myeloid, Acute / High-Throughput Nucleotide Sequencing / Mutation Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Nuclear Proteins / Base Sequence / Leukemia, Myeloid, Acute / High-Throughput Nucleotide Sequencing / Mutation Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article