Protective Effect of HP08-0111 on Ligature-Induced Periodontitis
International Journal of Oral Biology
;
: 145-151, 2010.
Article
in English
| WPRIM
| ID: wpr-92238
ABSTRACT
Periodontitis is an inflammatory disorder of the periodontium and is characterized by destruction of the tooth supporting tissues, mediated by the upregulation of synthesis and release of a variety of pro-inflammatory factors. Inflammatory cytokines and prostaglandins upregulate RANKL and its subsequent binding to RANK stimulates osteoclast formation, resorption activity, and survival. In our present study, we investigated the effects of HP08-0111, composed of Coptis japonica (Thunb.) Makino, vitamin C and vitamin E, upon inflammatory responses, osteoclastogenesis and alveolar bone loss. HP08-0111 decreased the expression of IL-1beta and COX2 on LPS-induced RAW 264.7 cells and inhibited osteoclast-specific genes such as c-Fos, MMP-9, and TRAP. HP08-0111 also exhibited protective effects against alveolar bone loss in rats with ligature-induced periodontitis. Our results suggest that HP08-0111 is potentially an important therapeutic tool for the treatment of disorders associated with bone loss such as periodontitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoclasts
/
Periodontitis
/
Ascorbic Acid
/
Tooth
/
Vitamin E
/
Vitamins
/
Periodontium
/
Up-Regulation
/
Prostaglandins
/
Alveolar Bone Loss
Limits:
Animals
Language:
English
Journal:
International Journal of Oral Biology
Year:
2010
Type:
Article
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