Effect of the course of treatment with broad-spectrum antibiotics on intestinal flora and short-chain fatty acids in feces of very low birth weight infants: a prospective study / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1008-1014, 2021.
Article
in English
| WPRIM
| ID: wpr-922383
ABSTRACT
OBJECTIVES@#To study the effect of the course of treatment with broad-spectrum antibiotics on intestinal flora and short-chain fatty acids (SCFAs) in feces of very low birth weight (VLBW) infants.@*METHODS@#A total of 29 VLBW infants who were admitted to the Neonatal Diagnosis and Treatment Center of Children's Hospital Affiliated to Chongqing Medical University from June to December 2020 were enrolled as subjects for this prospective study. According to the course of treatment with broad-spectrum antibiotics, they were divided into two groups ≤7 days (@*RESULTS@#There was a significant reduction in Chao index of the intestinal flora in the ≤7 days group and the >7 days group from week 2 to week 4 (@*CONCLUSIONS@#The course of treatment with broad-spectrum antibiotics can affect the abundance, colonization, and evolution of intestinal flora and the content of their metabolites SCFAs in VLBW infants. The indication and treatment course for broad-spectrum antibiotics should be strictly controlled in clinical practice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prospective Studies
/
Infant, Very Low Birth Weight
/
Fatty Acids, Volatile
/
Feces
/
Gastrointestinal Microbiome
/
Anti-Bacterial Agents
Type of study:
Observational study
Limits:
Child
/
Humans
/
Infant
/
Infant, Newborn
Language:
English
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2021
Type:
Article
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