Regulatory effects of miR-138 and RUNX3 on Th1/Th2 balance in peripheral blood of children with cough variant asthma / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1044-1049, 2021.
Article
in English
| WPRIM
| ID: wpr-922389
ABSTRACT
OBJECTIVES@#To study the expression levels of microRNA-138 (miR-138) and Runt-related transcription factor 3 (RUNX3) in peripheral blood of children with cough variant asthma (CVA) and their regulatory effects on Th1/Th2 balance.@*METHODS@#Sixty-five children with CVA (CVA group) and 30 healthy children (control group) were enrolled. Peripheral venous blood samples were collected for both groups, and CD4@*RESULTS@#Compared with the control group, the CVA group showed significantly decreased levels of IFN-γ and IL-2 from CD4@*CONCLUSIONS@#MiR-138 regulates Th1/Th2 balance by targeting RUNX3 in children with CVA, providing a new direction for the treatment of CVA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Th2 Cells
/
Th1 Cells
/
Interleukin-13
/
Cough
/
MicroRNAs
/
Core Binding Factor Alpha 3 Subunit
/
Th1-Th2 Balance
Limits:
Child
/
Humans
Language:
English
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2021
Type:
Article
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