Effect of high-fat diet for rats at different stages on glucose and lipid metabolism in offspring and related mechanisms / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1174-1183, 2021.
Article
in English
| WPRIM
| ID: wpr-922407
ABSTRACT
OBJECTIVES@#To study the effect of high-fat diet for maternal Sprague-Dawley rats at different stages on glucose and lipid metabolism in offspring and related mechanisms.@*METHODS@#According to the diet before pregnancy and during pregnancy and lactation, maternal rats were randomly divided into four groups (@*RESULTS@#Compared with the control diet groups (CC and CH groups), the groups with high-fat diet before pregnancy (HC and HH groups) had a significant increase in body weight (@*CONCLUSIONS@#High-fat diet for rats at different stages before and after pregnancy has different effects on glucose and lipid metabolism of offspring rats, and high-fat diet before pregnancy and during pregnancy and lactation has the greatest effect. The effect of high-fat diet on glucose and lipid metabolism of offspring rats is considered associated with the changes in the expression of genes involved in glucose and lipid metabolism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Body Weight
/
Insulin Resistance
/
Rats, Sprague-Dawley
/
Lipid Metabolism
/
Diet, High-Fat
/
Glucose
/
Insulin
/
Liver
Limits:
Animals
/
Pregnancy
Language:
English
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2021
Type:
Article
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