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Effect of high-fat diet for rats at different stages on glucose and lipid metabolism in offspring and related mechanisms / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 1174-1183, 2021.
Article in English | WPRIM | ID: wpr-922407
ABSTRACT
OBJECTIVES@#To study the effect of high-fat diet for maternal Sprague-Dawley rats at different stages on glucose and lipid metabolism in offspring and related mechanisms.@*METHODS@#According to the diet before pregnancy and during pregnancy and lactation, maternal rats were randomly divided into four groups (@*RESULTS@#Compared with the control diet groups (CC and CH groups), the groups with high-fat diet before pregnancy (HC and HH groups) had a significant increase in body weight (@*CONCLUSIONS@#High-fat diet for rats at different stages before and after pregnancy has different effects on glucose and lipid metabolism of offspring rats, and high-fat diet before pregnancy and during pregnancy and lactation has the greatest effect. The effect of high-fat diet on glucose and lipid metabolism of offspring rats is considered associated with the changes in the expression of genes involved in glucose and lipid metabolism.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Body Weight / Insulin Resistance / Rats, Sprague-Dawley / Lipid Metabolism / Diet, High-Fat / Glucose / Insulin / Liver Limits: Animals / Pregnancy Language: English Journal: Chinese Journal of Contemporary Pediatrics Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Body Weight / Insulin Resistance / Rats, Sprague-Dawley / Lipid Metabolism / Diet, High-Fat / Glucose / Insulin / Liver Limits: Animals / Pregnancy Language: English Journal: Chinese Journal of Contemporary Pediatrics Year: 2021 Type: Article