A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease

Ting LEI; Zhihang YANG; Xue XIA; Yuxiu CHEN; Xiaotong YANG; Rou XIE; Fan TONG; Xiaolin WANG; Huile GAO

Ting LEI; Zhihang YANG; Xue XIA; Yuxiu CHEN; Xiaotong YANG; Rou XIE; Fan TONG; Xiaolin WANG; Huile GAO.

Acta Pharmaceutica Sinica B ; (6): 4032-4044, 2021.

Article in English | WPRIM | ID: wpr-922458

ABSTRACT

ABSTRACT

Insurmountable blood‒brain barrier (BBB) and complex pathological features are the key factors affecting the treatment of Alzheimer's disease (AD). Poor accumulation of drugs in lesion sites and undesired effectiveness of simply reducing A

Alzheimer's disease; Anti-inflammatory; Autophagy; Aβ-capturing; Blood‒brain barrier transcytosis; Lesion targeting; Microenvironment modulation; ROS-responsive

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article