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Change of gene expression profiles in human cardiomyocytes and macrophages infected with SARS / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 1203-1211, 2021.
Article in English | WPRIM | ID: wpr-922603
ABSTRACT
OBJECTIVES@#Coronavirus disease 2019 (COVID-19) is an acute respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 can damage the myocardium directly, or activate the immune system, trigger a cytokine storm, and cause inflammatory cells to infiltrate the myocardial tissue and damage the myocardium. This study is based on the sequencing data to analyze the changes in gene expression of cardiomyocytes and macrophages after SARS-CoV-2 infection, and explore the potential effects of SARS-CoV-2 on the heart and immune system.@*METHODS@#The public data set GSE151879 was retrieved. The online software Network Analyst was used to preprocess the data, and the differentially expressed genes (DEGs) [log@*RESULTS@#After data standardization, the data quality was excellent and it can ensure reliable results. Myocardial cell infection with SARS-CoV-2 and gene expression spectrum were changed significantly, including a total of 484 DEGs in adult cardiomyoblasts, a total of 667 DEGs in macrophages, and a total of 1 483 DEGs in human embryo source of cardiomyopathy. The Stum, mechanosensory transduction mediator homolog (STUM), dehydrogenase/reductase 9 (DHRS9), calcium/calmodulin dependent protein kinase II beta (CAMK2B), claudin 1(CLDN1), C-C motif chemokine ligand 2 (CCL2), TNFAIP3 interacting protein 3 (TNIP3), G protein-coupled receptor 84 (GPR84), and C-X-C motif chemokine ligand 1 (CXCL1) were identical in expression patterns in 3 types of cells. The protein-protein interaction suggested that CAMK2B proteins may play a key role in the antiviral process in 3 types of cells; and silicon dioxide (SiO@*CONCLUSIONS@#CAMK2B, CLDN1, CCL2, and DHRS9 genes play important roles in the immune response of cardiomyocytes against SARS-CoV-2. SiO
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Silicon Dioxide / Myocytes, Cardiac / Transcriptome / SARS-CoV-2 / COVID-19 / Macrophages Limits: Humans Language: English Journal: Journal of Central South University(Medical Sciences) Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Silicon Dioxide / Myocytes, Cardiac / Transcriptome / SARS-CoV-2 / COVID-19 / Macrophages Limits: Humans Language: English Journal: Journal of Central South University(Medical Sciences) Year: 2021 Type: Article