Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 1325-1338, 2021.
Article
in English
| WPRIM
| ID: wpr-922632
ABSTRACT
A strong animal survival instinct is to approach objects and situations that are of benefit and to avoid risk. In humans, a large proportion of mental disorders are accompanied by impairments in risk avoidance. One of the most important genes involved in mental disorders is disrupted-in-schizophrenia-1 (DISC1), and animal models in which this gene has some level of dysfunction show emotion-related impairments. However, it is not known whether DISC1 mouse models have an impairment in avoiding potential risks. In the present study, we used DISC1-N terminal truncation (DISC1-N
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parvalbumins
/
Mice, Transgenic
/
Interneurons
/
Nerve Tissue Proteins
/
Neurons
/
Nucleus Accumbens
Type of study:
Etiology study
Limits:
Animals
Language:
English
Journal:
Neuroscience Bulletin
Year:
2021
Type:
Article
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