Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice

Zhixin PENG; Xiaoheng LI; Jun LI; Yuan DONG; Yuhao GAO; Yajin LIAO; Meichen YAN; Zengqiang YUAN; Jinbo CHENG

Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice / 神经科学通报·英文版

Zhixin PENG; Xiaoheng LI; Jun LI; Yuan DONG; Yuhao GAO; Yajin LIAO; Meichen YAN; Zengqiang YUAN; Jinbo CHENG.

Neuroscience Bulletin ; (6): 1671-1682, 2021.

Article in English | WPRIM | ID: wpr-922661

ABSTRACT

ABSTRACT

Microglia-mediated neuroinflammation is widely perceived as a contributor to numerous neurological diseases and mental disorders including depression. Discs large homolog 1 (Dlg1), an adaptor protein, regulates cell polarization and the function of K

Subject(s)

Animals; Mice; Depression/chemically induced; Inflammation; Lipopolysaccharides/toxicity; Mice, Inbred C57BL; Mice, Knockout; Microglia; NF-kappa B; Neuroinflammatory Diseases

Depression; Dlg1; Microglia; Neuroinflammation

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Lipopolysaccharides / NF-kappa B / Microglia / Mice, Knockout / Depression / Neuroinflammatory Diseases / Inflammation / Mice, Inbred C57BL Limits: Animals Language: English Journal: Neuroscience Bulletin Year: 2021 Type: Article

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