Discovery of Eucalyptin C, derived from the fruits of Eucalyptus globulus Labill., as a novel selective PI3Kγ inhibitor for immunosuppressive treatment / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 844-855, 2021.
Article
in English
| WPRIM
| ID: wpr-922767
ABSTRACT
The fruits of Eucalyptus globulus Labill. are known to have a plenty of medicinal properties, such as anti-tumor, anti-inflammatory, and immunosuppressive activity. Our previous study found that the phloroglucinol-sesquiterpene adducts in the fruits of E. globulus were immunosuppressive active constituents, especially Eucalyptin C (EuC). Phosphoinositide 3-kinases-γ (PI3Kγ) plays a pivotal role in T cell mediated excessive immune responses. In this study, EuC was first discovered to be a novel selective PI3Kγ inhibitor with an IC
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Flavonoids
/
Eucalyptus
/
Molecular Docking Simulation
/
Fruit
/
Phosphoinositide-3 Kinase Inhibitors
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2021
Type:
Article
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