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Cytotoxic diaporindene and tenellone derivatives from the fungus Phomopsis lithocarpus / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 874-880, 2021.
Article in English | WPRIM | ID: wpr-922770
ABSTRACT
Nine new compounds, including five natural rarely-occurring 2, 3-dihydro-1H-indene derivatives named diaporindenes E-I (1-5), and four new benzophenone analogues named tenellones J-M (6-9) were isolated from the deep-sea sediment-derived fungus Phomopsis lithocarpus FS508. All the structures for these new compounds were fully characterized on the basis of spectroscopic data, NMR spectra, and ECD calculation and single-crystal X-ray diffraction analysis. The potential anti-tumor activities of compounds 1-9 against four tumor cell lines SF-268, MCF-7, HepG-2, and A549 were evaluated using the SRB method. Compound 7 exhibited cytotoxic activity against the SF-268 cell line with an IC
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Molecular Structure / Crystallography, X-Ray / Cell Line, Tumor / Fungi / Phomopsis / Antineoplastic Agents Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Molecular Structure / Crystallography, X-Ray / Cell Line, Tumor / Fungi / Phomopsis / Antineoplastic Agents Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2021 Type: Article