Distribution of pathogenic bacteria and levels of inflammatory factors in hospitalized patients with pulmonary infection / 公共卫生与预防医学

ABSTRACT

Objective To analyze the distribution of pathogenic bacteria and the level of inflammatory factors in hospitalized patients with pulmonary infection. Methods A total of 516 inpatients with pulmonary infection in our hospital from January 2016 to April 2021 were randomly selected. According to the acute physiological and chronic health status score (APACHE II) within 24 hours after admission, they were divided into low-risk group (APACHE II score 20 points, 95 cases). In addition, 200 inpatients without pulmonary infection in the same period were selected as the control group. The sputum specimens of the observation group were cultured and identified by automatic microbial analyzer. The levels of procalcitonin (PCT), tumor necrosis factor -α(TNF-α) and hypersensitive C-reactive protein (hs-CRP) in the two groups were detected by ELISA. Results A total of 643 strains of pathogenic bacteria were detected in patients with pulmonary infection, among which 169 strains (26.28%) were gram-positive bacteria, mainly 93 strains (14.46%) of Staphylococcus aureus, 57 strains (8.86%) of streptococcus pneumoniae. There were 429 strains (66.72%) of gram-negative bacteria, mainly 187 strains (29.08%) of Acinetobacter baumannii and 163 strains (25.35) of Klebsiella pneumoniae. There were 45 strains of fungi (7.00%). Serum PCT, TNF-α and hs-CRP levels in experimental group were significantly higher than those in control group (t1=27.167, t2=6.419, t3=34.591, P<0.05). The serum levels of PCT, TNF-α and hs-CRP in high-risk group were significantly higher than those in medium-risk and low-risk groups (P<0.05); Serum PCT, TNF-α and hs-CRP levels in medium-risk group were significantly higher than those in low-risk group (P<0.05); Pearson correlation analysis showed that PCT, TNF-α and hs-CRP were significantly positively correlated with the severity of pulmonary infection in hospitalized patients (r=0.725, 0.617, 0.679, P<0.05). Conclusion Acinetobacter baumannii, Klebsiella pneumoniae and Staphylococcus aureus were the main pathogenic bacteria in hospitalized patients with pulmonary infection. The levels of inflammatory factors in patients with pulmonary infection were significantly increased, which could be used to assess the severity of the patient's disease..