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The role of Axin2+ cells in periodontal tissue development and regeneration / 口腔疾病防治
Journal of Prevention and Treatment for Stomatological Diseases ; (12): 433-437, 2022.
Article in Chinese | WPRIM | ID: wpr-923369
ABSTRACT
@#As a highly conserved signal pathway in evolution, the WNT signaling pathway plays an essential role in periodontium growth, development and injury repair. The Axin-associated protein Axin2 is a direct effector molecule of the WNT signaling pathway and labels WNT-responsive cells well. Studies have shown that Axin2-positive (Axin2+) cells in the periodontium have the potential for self-renewal, replication and multidirectional differentiation. This article reviews the temporal and spatial distribution of Axin2+ cells in periodontal tissue development and the role and regulatory mechanism of Axin2+ cells in periodontal tissue development, regeneration and tissue remodeling to provide new ideas for periodontal tissue regeneration. The literature review showed that Axin2+ cells were the main cell source of periodontium development, and Axin2+ cells played essential roles in tooth extraction socket healing, implant osseointegration, periodontal tissue remodeling and junctional epithelium regeneration. The function of Axin2+ cells was positively regulated by the canonical WNT signaling pathway. However, the regulatory mechanisms of other signaling pathways on Axin2+ cells remain to be elucidated.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Prevention and Treatment for Stomatological Diseases Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Prevention and Treatment for Stomatological Diseases Year: 2022 Type: Article