Relationship between Single Nucleotide Polymorphisms in Seven Sites of KCNQ1 and Susceptibilities to Exercise in Prediabetes / 中国康复理论与实践

ABSTRACT

@#Objective To observe the relationship between 7 single nucleotide polymorphisms (SNPs) in KCNQ1 gene region and the effects of exercise intervention on prediatbets. Methods From January, 2015, 70 prediabetes accepted aerobic endurance exercise for twelve weeks. The indexes related to glucose and lipid metabolism were measured before and after intervention. Their genotypes of SNPs were detected with matrix-assisted laser desorption/ionization time of flight mass spectrometry. Results A total of 66 cases finished the tests. Compared with other genotypes of rs2299620, two hours postprandial blood glucose (P2hBG) decreased the most in those with TT genotype (F=5.460, P<0.05). Compared with other haplotypes, P2hBG decreased more in those with C-T haplotype of rs2237897-rs2299620, T-C haplotype of rs2299620-rs151290 and T-T haplotype of rs2299620-rs2237892 (χ2>7.950, P<0.05), fasting insulin decreased more in those with T-C haplotype of rs2237897-rs2299620 (χ2=9.000, P<0.05), and low density lipoprotein decreased more in those with A-C haplotype of rs2283228-rs2237892 (χ2=15.820, P<0.001).Conclusion The prediatbets with TT genotype of rs2299620 and some haplotypes of KCNQ1 are susceptible to exercise intervention in glucose and lipid metabolism.