Predictive value of low-density lipoprotein cholesterol in cardiovascular events in elderly diabetic patients / 公共卫生与预防医学

ABSTRACT

Objective To analyze the predictive value of low-density lipoprotein cholesterol (LDL-c) on cardiovascular events in elderly patients with diabetes, and to provide theoretical guidance for the prevention of cardiovascular disease in elderly patients with diabetes. Methods A total of 180 elderly patients with diabetes treated at the Department of Cardiovascular Medicine, Hubei Jianghan Oilfield General Hospital from June 2019 to June 2020 were selected. According to the LDL-c level, they were divided into low-risk group (LDL-c 0.05). The serum TG, TC, and LDL-c levels, and Gensini scores in the high-risk group were significantly higher than those in the low-risk group, and the serum LDL-c level in the high-risk group was significantly lower than that in the low-risk group (P2=7.500, P<0.05). Spearman correlation analysis showed that LDL-C was positively correlated with the incidence of MACE (r=0.781, P<0.05). Multivariate logistic regression analysis showed that LDL-c≥2.6mmol/L was an independent risk factor for cardiovascular disease in elderly diabetic patients (P<0.05). The area under ROC curve for LDL-c to predict cardiovascular events in DM patients was 0.814 (95%CI0.767~0.912), and the sensitivity and specificity were 78.40% and 84.80%, respectively. Conclusion LDL-c level is significantly increased in elderly patients with diabetes, and LDL-c≥2.6 mmol/L is of certain value in predicting cardiovascular events in patients with diabetes.