Correlation between higher serum uric acid and glycolipid metabolism in college students / 中国学校卫生

ABSTRACT

Objective@#To explore the epidemiological characteristics of elevated serum uric acid in college students and its association with glycolipid metabolism, providing reference for health care intervention and education of college students.@*Methods@#From September 2020 to November 2021, a retrospective study was conducted among 989 college students in Taizhou area by stratified cluster random sampling method, and a questionnaire was issued to all college students. Serum uric acid (SUA), high density lipoprotein (HDL), low density lipoprotein (LDL), fasting plasma glucose(FPG), 2 h postprandial blood glucose (2 hPG), total cholesterol (TC), triglyceride (TG) levels were detected by urease immunoassay and enzyme linked immunosorbent assay.@*Results@#Waist circumference, body mass index, systolic blood pressure and diastolic blood pressure in higher serum uric acid group were higher than those in normal group ( t =21.72,5.74,5.45,12.23, P <0.05). The SUA, FPG, TG, 2 hPG, LDL and TC in serum uric acid increased group were higher than those in normal group, while HDL was lower than those in normal group ( t =13.85, 23.97, 10.24, 7.62, 34.91, 8.27, -8.15, P <0.05). Pearson correlation analysis showed that the levels of FPG, TG, 2 hPG, LDL and TC were positively correlated with SUA levels ( r =0.63, 0.72, 0.69, 0.16, 0.81, P <0.01). HDL was negatively correlated with SUA level ( r = -0.52, P <0.01). The glucolipid metabolism indexes were included into the binary Logistic regression model analysis, and the results showed that FPG, TG, LDL and TC were positively correlated with higher serum uric acid. HDL was negatively correlated with the incidence of higher serum uric acid ( P <0.05).@*Conclusion@#Male sex, alcohol consumption, smoking, and elevated blood pressure can contribute to higher serum uric acid, which has been found to be associated with glycolipid metabolism.