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Combined Administration of Shinbuto and Boiogito Prevents the Progression of Chronic Kidney Disease with Minimal Proteinuria in the Long-term (Part 2) / 日本東洋医学雑誌
Kampo Medicine ; : 378-383, 2020.
Article in Japanese | WPRIM | ID: wpr-924516
ABSTRACT
We previously reported that combined administration of shinbuto and boiogito extracts prevented the pro­gression of chronic kidney disease (CKD) over an observation period of 6 months. In the current study, we ex­tended the observation period to 60 months to investigate the long­-term effect of combined drug treatment. The subjects were 24 outpatients with CKD (14 men and 10 women ; mean age, 75.9 years) at the Department of Nephrology of Kagawaken Saiseikai Hospital. Shinbuto extract granules 5 g and boiogito extract granules 5 g were prescribed in two divided doses daily (before breakfast and dinner). Laboratory tests were performed before and 12, 24, 36, 48, and 60 months after drug administration. Although the treatment was discontinued in 14 patients because of reasons including patients' own volition, transfer to other hospitals, and emergence of proteinuria, 10 patients completed 60 months of treatment. Both the mean serum creatinine level (1.78 mg/dL before treatment ; 1.75 mg/dL after 60 months of treatment) and estimated glomerular filtration rate level (30.20 mL/min before treatment ; 34.39 mL/min after 60 months of treatment) did not deteriorate during the study period. Kidney test results persistently and significantly improved compared to the pre-­treatment results in 7 patients in whom the activities of daily living was stabilized. Taken together, we believe that long­-term treatment with shinbuto and boiogito extracts is effective for preventing the progression of CKD, which may be associated with nephrosclerosis, to advanced kidney failure.

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Index: WPRIM (Western Pacific) Language: Japanese Journal: Kampo Medicine Year: 2020 Type: Article

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Index: WPRIM (Western Pacific) Language: Japanese Journal: Kampo Medicine Year: 2020 Type: Article