Role of T cells in ischemic acute kidney injury and repair
The Korean Journal of Internal Medicine
;
: 534-550, 2022.
Article
in English
| WPRIM
| ID: wpr-927018
ABSTRACT
Ischemic acute kidney injury (AKI) is a common medical problem with significant mortality and morbidity, affecting a large number of patients globally. Ischemic AKI is associated with intrarenal inflammation as well as systemic inflammation; thus, the innate and adaptive immune systems are implicated in the pathogenesis of ischemic AKI. Among various intrarenal immune cells, T cells play major roles in the injury process and in the repair mechanism affecting AKI to chronic kidney disease transition. Importantly, T cells also participate in distant organ crosstalk during AKI, which affects the overall outcomes. Therefore, targeting T cell-mediated pathways and T cell-based therapies have therapeutic promise for ischemic AKI. Here, we review the major populations of kidney T cells and their roles in ischemic AKI.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2022
Type:
Article
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