Research progress of pharmacokinetic factors of metformin / 中国药房
China Pharmacy
;
(12): 1513-1519, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-927201
ABSTRACT
Metformin is the most common first-line oral hypoglycemic drug ,but there are large individual differences in pharmacokinetic parameters and pharmacodynamics during clinical use. The dosage of some patients should be adjusted to achieve satisfactory therapeutic effect. Pharmacokinetic parameters of metformin are affected by many factors ,including respects of transporter gene polymorphism ,drug interaction ,intestinal flora ,plateau hypoxia and physiological function and so on. In order to guide the clinical individualized use of metformin ,this study reviews the research progress on the influencing factors of metformin pharmacokinetics.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2022
Type:
Article
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