Driving role of macrophages in transition from acute kidney injury to chronic kidney disease / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 757-766, 2022.
Article
in English
| WPRIM
| ID: wpr-927566
ABSTRACT
Acute kidney injury (AKI), characterized by acute renal dysfunction, is an increasingly common clinical problem and an important risk factor in the subsequent development of chronic kidney disease (CKD). Regardless of the initial insults, the progression of CKD after AKI involves multiple types of cells, including renal resident cells and immune cells such as macrophages. Recently, the involvements of macrophages in AKI-to-CKD transition have garnered significant attention. Furthermore, substantial progress has also been made in elucidating the pathophysiological functions of macrophages from the acute kidney to repair or fibrosis. In this review, we highlight current knowledge regarding the roles and mechanisms of macrophage activation and phenotypic polarization, and transdifferentiation in the development of AKI-to-CKD transition. In addition, the potential of macrophage-based therapy for preventing AKI-to-CKD transition is also discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Disease Progression
/
Renal Insufficiency, Chronic
/
Acute Kidney Injury
/
Kidney
/
Macrophages
Limits:
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2022
Type:
Article
Similar
MEDLINE
...
LILACS
LIS