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Phagocytosis of microglia in neurodegenerative diseases / 生理学报
Acta Physiologica Sinica ; (6): 283-293, 2022.
Article in Chinese | WPRIM | ID: wpr-927604
ABSTRACT
With the acceleration of the aging society, neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), have become a rapidly growing global health crisis. Recent studies have indicated that microglia-neuron interactions are critical for maintaining homeostasis of the central nervous system. Genome-Wide Association Studies and brain imaging studies have suggested that microglia are activated in early stage of neurodegenerative diseases. Microglia are specialized phagocytes in the brain. The discovery of a new phagocytic pathway, trogocytosis, suggests that there is a close interaction between microglia and surviving neurons. In this review, we summarize the important roles of microglia in neurodegenerative diseases, and further analyze the functions and molecular mechanisms of microglia phagocytosis and trogocytosis.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Phagocytosis / Microglia / Neurodegenerative Diseases / Genome-Wide Association Study / Alzheimer Disease Limits: Humans Language: Chinese Journal: Acta Physiologica Sinica Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phagocytosis / Microglia / Neurodegenerative Diseases / Genome-Wide Association Study / Alzheimer Disease Limits: Humans Language: Chinese Journal: Acta Physiologica Sinica Year: 2022 Type: Article