Biological function of Nogo-B receptor / 生理学报
Acta Physiologica Sinica
;
(6): 301-308, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-927606
ABSTRACT
Nogo-B receptor (NgBR) is a specific receptor of Nogo-B, a member of reticulon 4 protein family. It is widely expressed in many tissues and mainly located in cell membrane and endoplasmic reticulum. Previous studies have revealed that NgBR is involved in a variety of physiological and pathophysiological processes, such as dolichol synthesis, lipid metabolism, cholesterol trafficking, insulin resistance, vascular remodeling and angiogenesis, tumorigenesis and nervous system diseases. Further studies on the molecular characteristics and biological function of NgBR might be of great significance to understand its role in diverse diseases and provide possible clinical strategies for the treatment of diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Carrier Proteins
/
Receptors, Cell Surface
/
Endoplasmic Reticulum
/
Lipid Metabolism
/
Nogo Proteins
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2022
Type:
Article
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