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Application of Nanopore Sequencing Technology in the Clinical Diagnosis of Infectious Diseases / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 381-392, 2022.
Article in English | WPRIM | ID: wpr-927677
ABSTRACT
Infectious diseases are an enormous public health burden and a growing threat to human health worldwide. Emerging or classic recurrent pathogens, or pathogens with resistant traits, challenge our ability to diagnose and control infectious diseases. Nanopore sequencing technology has the potential to enhance our ability to diagnose, interrogate, and track infectious diseases due to the unrestricted read length and system portability. This review focuses on the application of nanopore sequencing technology in the clinical diagnosis of infectious diseases and includes the following (i) a brief introduction to nanopore sequencing technology and Oxford Nanopore Technologies (ONT) sequencing platforms; (ii) strategies for nanopore-based sequencing technologies; and (iii) applications of nanopore sequencing technology in monitoring emerging pathogenic microorganisms, molecular detection of clinically relevant drug-resistance genes, and characterization of disease-related microbial communities. Finally, we discuss the current challenges, potential opportunities, and future outlook for applying nanopore sequencing technology in the diagnosis of infectious diseases.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Technology / Communicable Diseases / Sequence Analysis, DNA / High-Throughput Nucleotide Sequencing / Microbiota / Nanopore Sequencing Type of study: Diagnostic study Limits: Humans Language: English Journal: Biomedical and Environmental Sciences Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Technology / Communicable Diseases / Sequence Analysis, DNA / High-Throughput Nucleotide Sequencing / Microbiota / Nanopore Sequencing Type of study: Diagnostic study Limits: Humans Language: English Journal: Biomedical and Environmental Sciences Year: 2022 Type: Article