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Correlations between genetic polymorphism of IFN-λ family gene and HBV infection, virus replication and clearance / 生物工程学报
Chinese Journal of Biotechnology ; (12): 893-902, 2022.
Article in Chinese | WPRIM | ID: wpr-927752
ABSTRACT
Hepatitis B virus (HBV) infection is one of the most serious public health problems. HBV infection could lead to hepatitis B, and even further develop into hepatic cirrhosis and hepatocellular carcinoma. Interferon lambda (IFN-λ) is a member of the interferon (IFN) family and an important cytokine for antiviral defense. There are four members in IFN-λ family, including IFN-λ1, IFN-λ2, IFN-λ3, and IFN-λ4. The genetic polymorphisms in the IFN-λ genes are associated with HBV replication and treatment response of HBV patients. In this review, we summarized the roles of genetic polymorphisms of the IFN-λ genes played in HBV infection, disease progression and treatment, with the aim to better understand their function. This review could serve as a reference for the HBV prevention and treatment of HBV patients, as well as for future clinical usage.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Polymorphism, Genetic / Virus Replication / Hepatitis B virus / Interferons / Hepatitis B / Liver Neoplasms Limits: Humans Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Polymorphism, Genetic / Virus Replication / Hepatitis B virus / Interferons / Hepatitis B / Liver Neoplasms Limits: Humans Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2022 Type: Article