Advances in N-methyl-D-aspartate Receptor Signaling Pathway and Mechanism of the Pathway-mediated Apoptosis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 149-157, 2022.
Article
in Zh
| WPRIM
| ID: wpr-927859
Responsible library:
WPRO
ABSTRACT
N-methyl-D-aspartate receptor (NMDAR),an important ionic glutamate receptor and a ligand and voltage-gated ion channel characterized by complex composition and functions and wide distribution,plays a key role in the pathological and physiological process of diseases or stress states.NMDAR can mediate apoptosis through different pathways such as mitochondrial and endoplasmic reticulum damage,production of reactive oxygen species and peroxynitrite,and activation of mitogen-activated protein kinase and calpain.This paper reviews the structure,distribution,and biological characteristics of NMDAR and the mechanisms of NMDAR-mediated apoptosis.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Signal Transduction
/
Reactive Oxygen Species
/
Apoptosis
/
Receptors, N-Methyl-D-Aspartate
/
Mitogen-Activated Protein Kinases
Limits:
Humans
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2022
Type:
Article